This thesis is dedicated to the fundamental and applied studies of electrokinetic transport and manipulation of particles in various curved microchannels using a combined experimental, theoretical, and numerical method. Jan 06, 2015 ion, particle, and fluid transport in nanofluidic devices has received considerable attention over the past two decades due to unique transport properties exhibited at the nanoscale. Pdf microfluidic technology and its biomedical applications. This text focuses on the physics of fluid transport in micro and nanofabricated liquidphase systems, with consideration of gas bubbles, solid particles, and macromolecules. Modeling electrokinetic phenomana in micro and nanofluidics s. Disposable electrokinetic micro preconcentrator for proteomic sample preparation using pdms microfluidic chip. Dec 20, 2012 lectures are from cornell university mechanical engineering 6240 physics of micro and nanoscale fluid mechanics. Numerous applications of micronanofluidics are related to particle transport in micronanoscale channels, and electrokinetics has proved to be one of the most. Therefore, a comprehensive understanding of electrokinetic particle transport in micro nanoscale channels is crucial to the development of micro nanofluidic devices.
This text was designed with the goal of bringing together several areas that are often taught separately namely, fluid mechanics, electrodynamics, and interfacial chemistry and electrochemistry. The book emphasizes the direct numerical simulation of electrokinetic particle transport phenomena, plus several supportive experimental studies. Electrokinetic assembly of microsphere and cellular arrays. The book emphasizes the direct numerical simulation of.
We present a numerical analysis framework to investigate two critical electrokinetic phenomena underlying the experimental observation in plecis et al. Microvalve using inducedcharge electrokinetic motion of. Therefore, the main objective of this study is to demonstrate localized flow control in micro geometries using a leakagecurrent based fieldeffect transistor formed on pdms. Pdf microfluidics is the field of handling small volume of fluids andor manipulating. The process involves generation of fluid flow by pressure difference, particle trapping by dep force, and particle redirect by eo and ep forces. We start with an introduction into the theoretical basis of ion transport kinetics and their analogy. Field effect control of electrokinetic transport in micro nanofluidics article in sensors and actuators b chemical 1611. Ion, particle, and fluid transport in nanofluidic devices has received considerable attention over the past two decades due to unique transport properties exhibited at the nanoscale. Field effect control of surface charge property and electroosmotic flow in nanofluidics.
The biggest challenge to model the electrokinetic transport using atomistic simulations is the extensive cost in calculation of the longrange electrostatic force between. A thesis presented to the graduate school of clemson university in partial fulfillment of the requirements for the degree master of science mechanical engineering by. Disposable electrokinetic micro preconcentrator for. Direct numerical simulation analysis surfactant science book 153 kindle edition by qian, shizhi, ai, ye. A janus particle with a conducting hemisphere and a nonconducting hemisphere is placed in a junction of several microchannels. Home research electrokinetic phenomena for an enhanced understanding of ongoing atomic force microscopy afm measurements, i have been working on the numerical modeling of the afm tip 5nm interacting with a flat substrate immersed in an ionic solution. Field effect control of electrokinetic transport in micronanofluidics article in sensors and actuators b chemical 1611. Electrokinetics is an attractive method for integrating particle.
Particle tracking techniques for electrokinetic microchannel flows shankar devasenathipathy and juan g. Electrokinetic transport phenomena in microfluidics. There has been a growing interest in developing onlabachip micronanofluidic systems for biodetection, biotechnology, chemical and biological reactors, and medical. Initial, twocomponent particle tracking studies in electrokinetic flows include that of devasenathipathy et al. Electrokinetic particle transport in micronanofluidics. Considering vast area of micro and nanofluidics, we restrict our attention to electrokinetic flows, which have been studied with relatively less focus on freesurface dynamics. Therefore, the main objective of this study is to demonstrate localized flow control in microgeometries using a leakagecurrent based fieldeffect transistor formed on pdms. Numerical analysis of electrokinetic transport in micro. The analytical solutions indicate that pressuredriven flow of an electrolyte solution in microchannel with charged solid wall induces a streaming.
Direct numerical simulation analysis provides a fundamental understanding of electrokinetic particle transport in micro. We start with an introduction into the theoretical basis of ion transport kinetics and their analogy to the charge transport in electronic systems. Lectures are from cornell university mechanical engineering 6240 physics of micro and nanoscale fluid mechanics. Molecular simulation of electrokinetic transport in nanofluidics. Yang school of mechanical and aerospace engineering nanyang technological university, 50 nanyang avenue, singapore 639798 abstract in this study, we propose the implementation of the inducedcharge electrokinetic icek flow in nanofluidics for the first time. Here the selection of our reference to previous related works will be purely based on convenience, and by no means rigorous. Electrokinetic assembly of microsphere and cellular arrays mihrimah ozkan1, sadik c. Electrokinetic phenomena in pencil leadbased microfluidics mdpi. Disposable electrokinetic micro preconcentrator for proteomic.
Modeling electrokinetic phenomana in micro and nanofluidics. Electrokinetic transport in micro and nano channels. Microelectrodes can be integrated into these devices to generate large electric fields and field gradients using low voltages. Therefore, a comprehensive understanding of electrokinetic particle transpo. Electrokinetic hydrogen generation from liquid water microjets andrew m. Electrokinetics is an attractive method for integrating particle manipulation and separation within such systems. Using the commercial finite element package comsol multiphysics, it guides researchers on how to predict the particle transport subjected to electric fields in micronanoscale channels. Pdf nanofluidics presents growing and exciting opportunities for conducting fundamental studies for processes and. Electrokineticallydriven microfluidics and nanofluidics. Inducedcharge electrokinetic flow in an asymmetric. Direct numerical simulation analysis surfactant science. Electrokinetic particle transport in micro nanofluidics. Nanopores are apertures of nanometric dimensions in an insulating matrix. Particle separation using electrokineticallydriven.
Yang school of mechanical and aerospace engineering, nanyang technological university, singapore abstract microfluidic manipulation of particulate matters has found its applications in cell handling, virus detection, biomolecule concentration and colloidal particle. Use features like bookmarks, note taking and highlighting while reading electrokinetic particle transport in micronanofluidics. In smallscale microfluidics processes, electroosmosis, electrothermal effects, and electrokinetic instabilities are responsible for fluid motion and electrophoresis and dielectrophoresis dep cause particle movement, such as in cells. Using numerical simulations based on coupled transient poisson. Santiago department of mechanical engineering, thermosciences division, building 500, room 501e, stanford university. Electrokinetic flow and electroviscous effect in a charged. Under an applied electric field, the inducedcharge electrokinetic flow around the. Chemically functionalized nanopores in solidstate membranes have recently emerged as versatile tools for regulating ion transport and sensing single biomolecules. Electrokinetic microfluidic device free download as powerpoint presentation. Freesurface problems in electrokinetic micro and nanofluidics. Both the simulation results and the experimental consequences show that through increasing the voltage, the ion concentration improves gradually first and then.
First, a fundamental study of particle electrokinetics in a microchannel uturn, a typical unit in loc devices, was investigated. A new micro valve using the electrokinetic motion of a janus particle is introduced in this paper. Automated or remote manipulation and analysis of particles and fluids is a key element in microfluidic devices. The electrokinetic forces are easy to control by designing optimum electrode structures and choice of field and frequency. Saykally 2007 the journal of physical chemistry c 111 12031. Dc electrokinetic particle transport in an lshaped microchannel. These can be utilized for flow, species and particle transport control applications in microfluidic systems. These can be utilized for flow, species and particle transport control applications in micro fluidic systems. Electrokinetic ion transport in nanofluidics and membranes.
Particles, encyclopedia of microfluidics and nanofluidics. Electrokinetic transport in nanofluidics has attracted many attentions in recent years due to its potential applications in biomedical analysis and energy conversion systems. Therefore, electrokinetic based microfluidic systems can serve as a viable tool in creating a labonachip loc or micro total analysis system. They are routinely used to sense and measure properties of single molecules such as dna. Additional equations for each component of translational and angular velocity of the particle are then obtained, and to be solved simultaneously with the other conservation. The particle motion is undetermined, so that the momentum and force balance must be invoked for closure. Labonchip systems integrate multiple functionalities on a single platform. Simulating electrokinetic phenomena in microfluidics. Bhattacharyya department of mathematics indian institute of technology, kharagpur 722, india.
There has recently been widespread interest in the use of ac electric. Electrokinetic flow diagnostics stanford university. Particle tracking techniques for electrokinetic microchannel. The nano electrokinetic thruster is a theoretical space propulsion system based on the principle of electroosmosis also electroosmotic flow. Electrokinetic transport process in nanopores generated on cell membrane during electroporation by saeid movahed a thesis presented to the university of waterloo in fulfillment of the thesis requirement for the degree of doctor of philosophy in mechanical engineering waterloo, ontario, canada, 2012 saeid movahed 2012. Highthroughput particle manipulation by hydrodynamic. It allows for a high specific impulse and high thrusttopower ratio as well as a high final velocity which makes it suitable for a. Electrokinetic flow and measure method in microfluidic. Numerous applications of micro nanofluidics are related to particle transport in micro nanoscale channels, and electrokinetics has proved to be one of the most promising tools to manipulate particles in micro nanofluidics. Molecular simulation of electrokinetic transport in. The poissonnernstplanck equations are employed to investigate the influence of the voltage on the ion concentration. Field effect control of electrokinetic transport in micro. Ac electrokinetic particle manipulation in microsystems.
The evolution dynamics of the vortices, presumably involving the merging of small. Electrokinetic ion breakdown in a nanochannel is demonstrated. Electrokinetic transport processes such as electroosmosis, induced charge electroosmosis iceo. An analytical solution for pressuredriven electrokinetic flows in a narrow capillary is presented based on the poissonboltzmann equation for electrical double layer and the navierstokes equations for incompressible viscous fluid. Field effect control of particle electrokinetic transport in m icronanofluidics due to the full coupling of the fluid and particle dynamics, electrostatics, and ionic mass transport described by the model in section 2. Highthroughput particle manipulation by hydrodynamic, electrokinetic, and dielectrophoretic effects in an integrated micro. These two vortices merge and form a highpressure zone through which two.
Numerous applications of micronanofluidics are related to particle transport in micronanoscale channels, and electrokinetics has proved to be one of the most promising tools to manipulate particles in micronanofluidics. Electrokinetic transport and manipulation of particles in microfluidic reservoirs. The electrokinetic phenomena were characterized by microparticle image. Superfast electrophoresis of conducting dispersed particles. It allows for a high specific impulse and high thrusttopower ratio as well as a high final velocity which makes it suitable for a wide variety of applications. Electrokinetic flow control in microfluidic chips using a. Web site describes electrokinetic techniques, miniaturized hplc, protein refolding, zeta. Electrokinetic phenomena in nanopore transport doctoral thesis. We demonstrated particle manipulation in an integrated microfluidic device by applying hydrodynamic, electroosmotic eo, electrophoretic ep, and dielectrophoretic dep forces. Electrokinetic transport and surface control gaspard pardon doctoral thesis in micro and nanosystems stockholm, sweden 2014 kth royal institute of technology.
Electrokinetic transport process in nanopores generated on. Electrokinetically driven microfluidics and nanofluidics electrokinetics is currently the mechanism of choice for. This study theoretically investigated the importance of the bulk salt concentration, the geometries of the nanopore, and both the thickness and t. Web page of microfluidics and nanofluidics laboratory at cornell university, directed by brian kirby in the mechanical and aerospace engineering department.
Download it once and read it on your kindle device, pc, phones or tablets. Trapping of submicron and micronsized particles using. Electrokinetic flow and electroviscous effect in a slit microchannel koreaaustralia rheology journal june 2003 vol. Web site describes electrokinetic techniques, miniaturized hplc, protein refolding, zeta potential and interface science, and other fun stuff.
1240 304 404 967 880 1020 1137 977 1160 581 1231 425 462 615 1061 661 214 712 797 479 159 132 521 1258 73 735 1226 249 525 823 308 819 405